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Results of Proof-of-concept study indicate that hsCRP may be valid indicator of Bisphenol A contamination, but finds that ubiquitous co-confounding factors may invalidate most other dietary interventions as now designed

NOTE: This is a draft still in progress (July 9, 2020). Edits and citations are actively being added. Results of investigation: Revised Protocol: UCSF IRB/CHR Number: 15-17703 Clinical blood profile assays as biomarkers to directly assess potential health effects resulting from the controlled elimination of suspected dietary and environmental chemical toxins. Co-principal investigators Dr. Victor […]

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Significant changes necessary in order for dietary intervention studies to be causal and replicable

Dietary intervention studies as a whole are inherently flawed and do not produce causal or clinically relevant health recommendations or decisions. Accuracy and replicability of any study depend upon using precise methods under identical conditions using identical materials, reagents, apparatus, and test subjects. Unfortunately, human dietary intervention studies in the scientific literature are fatally confounded […]

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Dosing of a single compound to establish causality in dietary interventions & enable clinically valid health decisions.

“Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the unknown and therefore uncontrolled variables in study populations and experimental designs.” — The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls Dietary studies are […]

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Micro- and Nanoplastics: Health Implications

Microplastics are generally those fragments that are less than five millimeters in size. However, a single microplastic fragment rarely stays the same size.   Whether found on dry land, in steams and oceans — or in your mouth as you chew, swallow and digest — natural and biological forces relentlessly reduce microplastics in size. Eventually, […]

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Yet another reason the Stealth Syndromes Human Study is needed

The Retraction Watch web site shared an article about null hypothesis testing — “Almost 40% of peer-reviewed dietary research turns out to be wrong” — which illustrates why direct, experimental studies on humans (like our study) can yield more accurate and reproducible data than statistical methods. This is not to say statistical methods are wrong […]

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The Importance of Addressing the Previously Unaddressable

The outcome of this study may make a substantial contribution by definitively and credibly evaluating the human effects of endocrine disruptors and other environmental chemicals. Regardless of whether the thesis of this study is proven or not, it will add vital data that can help scientists, health professionals, and the general public to understand risks […]

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Details: Moving from approved protocol to planning

The excitement built into the science of an approved study study eventually has to give way to the operational details grunt work. I have been compiling possible candidates for collaborators and labs to conduct the blood/EDC/epigenetic/DNA break testing. Designing the protocol for maximum compliance Before those tasks can be done properly, the success of the […]

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