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Author Archive | Lewis Perdue

Air pollution: Confounding factors for study

Air pollution confounding factors The Kincade Fire in northern Sonoma County started on October 23, 2019, was contained on Nov. 6 but continued to burn and affect the test location during and after the SSHS study was finished. Because PM 2.5 is a potent inflammatory agent, a monitoring device was purchased to track indoor air […]

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Inflammation, PM2.5 and serious health effects

Particulate pollution, especially those of 2.5 microns or smaller — has been demonstrated to cause, promote, or aggravate numerous serious health effects including inflammation and specific syndromes involving the immune system, diabetes, insulin resistance, metabolic syndrome, cardiovascular disease as well as neurological and psychological maladies. Reid CE, Brauer M, Johnston FH, Jerrett M, Balmes JR, […]

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Biomedical science and pharmaceutical research embrace n-of-1 trials

The use and scientific acceptance  of  “n-of-1” trials have accelerated in recent years, especially in connection with personalized medicine and drug discovery. This increase in interest and acceptance is reflected in the number of studies on the field. A Google Scholar search (July 26, 2020) for “n-of-1 trial validity” for all date ranges, yielded 3,430 […]

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Study procedures, methods, and best practices

Developing a scientifically sound set of methods for a dietary intervention that could result in replicable, causally valid results took investigators five years of intensive effort. That was a necessary first step because no such standards, protocols, methods or best practices existed. That absence required investigators to develop those standards and protocols de novo in […]

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UCSF IRB/CHR Approves study extension

2019-UCSF-CHR-IRB-study-Extension-to-102720 Human Research Protection Program Institutional Review Board (IRB) Expedited Review Approval Principal Investigator Victor I. Reus, MD Co-Principal Investigator Lewis Perdue Type of Submission: Continuing Review Submission Form Study Title: Clinical blood profile assays as biomarkers to directly assess potential health effects resulting from the controlled elimination of suspected dietary and environmental chemical toxins. […]

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Results of Proof-of-concept study indicate that hsCRP may be valid indicator of Bisphenol A contamination, but finds that ubiquitous co-confounding factors may invalidate most other dietary interventions as now designed

NOTE: This is a draft still in progress (July 9, 2020). Edits and citations are actively being added. Results of investigation: Revised Protocol: UCSF IRB/CHR Number: 15-17703 Clinical blood profile assays as biomarkers to directly assess potential health effects resulting from the controlled elimination of suspected dietary and environmental chemical toxins. Co-principal investigators Dr. Victor […]

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Additional posts incorporated in or used as references in primary articles

Primary articles Results of Proof-of-concept study indicate that hsCRP may be valid indicator of Bisphenol A contamination, but finds that ubiquitous co-confounding factors may invalidate most dietary interventions Significant changes necessary in order for dietary intervention studies to be causal and replicable Supplementary/ reference articles How food processing adds plastic-derived chemical contamination How does the […]

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Recent dietary interventions relevant to Plastic-Derived Chemicals

el, R.A., Gray, J.M., Engel, C.L., Rawsthorne, T.W., Dodson, R.E., Ackerman, J.M., Rizzo, J., Nudelman, J.L., and Brody, J.G. 2011. Food packaging and Bisphenol A and Bis(2-Ethyhexyl) Phthalate exposure: Findings from a dietary intervention. Environmental Health Perspectives 119(7): 914-920.  Sathyanarayana, S., Alcedo, G., Saelens, B.E., Zhou, C., Dills, R.L., Yu, J., and Lanphear, B. 2013. […]

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Significant changes necessary in order for dietary intervention studies to be causal and replicable

Dietary intervention studies as a whole are inherently flawed and do not produce causal or clinically relevant health recommendations or decisions. Accuracy and replicability of any study depend upon using precise methods under identical conditions using identical materials, reagents, apparatus, and test subjects. Unfortunately, human dietary intervention studies in the scientific literature are fatally confounded […]

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