Header

Archive | Featured

Results of Proof-of-concept study indicate that hsCRP may be valid indicator of Bisphenol A contamination, but finds that ubiquitous co-confounding factors may invalidate most other dietary interventions as now designed

NOTE: This is a draft still in progress (July 9, 2020). Edits and citations are actively being added. Results of investigation: Revised Protocol: UCSF IRB/CHR Number: 15-17703 Clinical blood profile assays as biomarkers to directly assess potential health effects resulting from the controlled elimination of suspected dietary and environmental chemical toxins. Co-principal investigators Dr. Victor […]

Continue Reading

Significant changes necessary in order for dietary intervention studies to be causal and replicable

Dietary intervention studies as a whole are inherently flawed and do not produce causal or clinically relevant health recommendations or decisions. Accuracy and replicability of any study depend upon using precise methods under identical conditions using identical materials, reagents, apparatus, and test subjects. Unfortunately, human dietary intervention studies in the scientific literature are fatally confounded […]

Continue Reading

Dosing of a single compound to establish causality in dietary interventions & enable clinically valid health decisions.

“Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the unknown and therefore uncontrolled variables in study populations and experimental designs.” — The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls Dietary studies are […]

Continue Reading

Basic scientific lab standards — Best practices for a replicable dietary intervention

NOTES: All of the best practices described below have been developed and hands-on tested in an actual dietary intervention study as feasible and minimally disruptive in a commercial-standard kitchen. The kitchen must be treated as a laboratory; a recipe is a protocol; foods are reagents; every item used in preparation and cooking is equipment and […]

Continue Reading

Micro- and Nanoplastics: Health Implications

Microplastics are generally those fragments that are less than five millimeters in size. However, a single microplastic fragment rarely stays the same size.   Whether found on dry land, in steams and oceans — or in your mouth as you chew, swallow and digest — natural and biological forces relentlessly reduce microplastics in size. Eventually, […]

Continue Reading

The Need & Difficulties of Controlling Micronutrients in The Diet of Test Subjects When Dealing With Endocrine & Epigenetic Disrupting Compounds

Designing the perfect experiment to answer the questions that you set out to study can be extremely complicated. There could be something in your protocol that you didn’t even think would be a problem that might turn out to be your worst nightmare.  For us, controlling for nutrition and diet might be a necessary component […]

Continue Reading

The Importance of Addressing the Previously Unaddressable

The outcome of this study may make a substantial contribution by definitively and credibly evaluating the human effects of endocrine disruptors and other environmental chemicals. Regardless of whether the thesis of this study is proven or not, it will add vital data that can help scientists, health professionals, and the general public to understand risks […]

Continue Reading

Details: Moving from approved protocol to planning

The excitement built into the science of an approved study study eventually has to give way to the operational details grunt work. I have been compiling possible candidates for collaborators and labs to conduct the blood/EDC/epigenetic/DNA break testing. Designing the protocol for maximum compliance Before those tasks can be done properly, the success of the […]

Continue Reading