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Inflammation, PM2.5 and serious health effects

Particulate pollution, especially those of 2.5 microns or smaller — has been demonstrated to cause, promote, or aggravate numerous serious health effects including inflammation and specific syndromes involving the immune system, diabetes, insulin resistance, metabolic syndrome, cardiovascular disease as well as neurological and psychological maladies.

Reid CE, Brauer M, Johnston FH, Jerrett M, Balmes JR, Elliott CT. Critical Review of Health Impacts of Wildfire Smoke Exposure. Environ Health Perspect. 2016;124(9):1334-1343. doi:10.1289/ehp.1409277

Feng S, Gao D, Liao F, Zhou F, Wang X. The health effects of ambient PM2.5 and potential mechanisms. Ecotoxicol Environ Saf. 2016;128:67-74. doi:10.1016/j.ecoenv.2016.01.030

Ohlwein S, Kappeler R, Kutlar Joss M, Künzli N, Hoffmann B. Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence. Int J Public Health. 2019;64(4):547-559. doi:10.1007/s00038-019-01202-7

Wei T, Tang M. Biological effects of airborne fine particulate matter (PM2.5) exposure on pulmonary immune system. Environ Toxicol Pharmacol. 2018;60:195-201. doi:10.1016/j.etap.2018.04.004

Miller MR. Oxidative stress and the cardiovascular effects of air pollution. Free Radic Biol Med. 2020;151:69-87. doi:10.1016/j.freeradbiomed.2020.01.004

Wolf K, Popp A, Schneider A, et al. Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines [published correction appears in Diabetes. 2017 Oct;66(10 ):2725]. Diabetes. 2016;65(11):3314-3326. doi:10.2337/db15-1567

Esposito K, Petrizzo M, Maiorino MI, Bellastella G, Giugliano D. Particulate matter pollutants and risk of type 2 diabetes: a time for concern?. Endocrine. 2016;51(1):32-37. doi:10.1007/s12020-015-0638-2

 

Pope CA 3rd, Turner MC, Burnett RT, et al. Relationships between fine particulate air pollution, cardiometabolic disorders, and cardiovascular mortality. Circ Res. 2015;116(1):108-115. doi:10.1161/CIRCRESAHA.116.305060
Xu MX, Ge CX, Qin YT, et al. Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia. Free Radic Biol Med. 2019;130:542-556. doi:10.1016/j.freeradbiomed.2018.11.016

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Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence

Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation

Ambient particulate air pollution and circulating C-reactive protein level: A systematic review and meta-analysis

Oxidative stress and the cardiovascular effects of air pollution

Ambient particulate air pollution and circulating C-reactive protein level: A systematic review and meta-analysis

Particulate Matter Exposure and Stress Hormone Levels

Shou Y, Huang Y, Zhu X, Liu C, Hu Y, Wang H. A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer’s disease. Ecotoxicol Environ Saf. 2019;174:344-352. doi:10.1016/j.ecoenv.2019.02.086

Jia Z, Wei Y, Li X, et al. Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing. Int J Environ Res Public Health. 2018;15(1):160. Published 2018 Jan 19. doi:10.3390/ijerph15010160

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Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility

Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics

Particulate Matter Air Pollution and Cardiovascular Disease

Associations of Short-Term and Long-Term Exposure to Ambient Air Pollutants With Hypertension

Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations

Fine Particulate Air Pollution (PM2.5) and the Risk of Acute Ischemic Stroke